Colloidal nanoparticles as advanced biological sensors

Colloidal stability of polymeric nanoparticles in biological fluids

Estimating the colloidal stability of polymeric nanoparticles (NPs) in biological environments is critical for designing optimal preparations and to clarify the fate of these devices after administration. To characterize and quantify the physical stability of nanodevices suitable for biomedical applications, spherical NPs composed of poly-lactic acid (PLA) and poly-methyl-methacrylate (PMMA), i...

Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents.

Biological molecular assemblies are excellent models for the development of nanoengineered systems with desirable biomedical properties. Here we report an approach for fabrication of spontaneous, biologically active molecular networks consisting of bacteriophage (phage) directly assembled with gold (Au) nanoparticles (termed Au-phage). We show that when the phage are engineered so that each pha...

“Cubic” Colloidal Platinum Nanoparticles

Transition metals have long been used as catalysts in the form of dispersions stabilized on inorganic substrates such as silica gel, alumina, and activated charcoal.1 More recently, colloidal platinum nanoparticles have been used as catalysts and photocatalysts in solutions.2 Aqueous colloidal platinum particles are mostly prepared by the reduction of a platinum salt by hydrogen, photochemical,...

lipid-based nanoparticles as promising colloidal drug carriers

Polarity sensitive colloidal gold nanoparticles

Water soluble colloidal nanoparticles possess huge surface negative charge and this provides their colloidal stability [1]. The surface charge, therefore, ultimately demonstrate the overall behavior of the nanoparticles irrespective of core material. We demonstrate fluorescence based dual emission polarity sensor that is based upon hydroxyflavone derivative [2]. The NH2 group at position 7 faci...